Toxic action of platinum coordination complexes on the endocrine pancreas of the rat.

Reports on toxic effects of platinum coordination complexes on the endocrine pancreas are missing with exception of cis-DDP itself (Goldstein et al 1983). Recently, oxoplatin (trans-dihydroxy-cis-dichlorodiammine-platinum [IV]) an oxygenated derivative of cis-DDP has been described by Presnov and Konovalova (1988), Fig. 1. As indicated by the maximally tolerated dose levels, oxoplatin has been found to be about 3 times less toxic than cis-DDP when administered daily to rats for 5 consecutive days (Hartl et al 1989). Starting from preclinical screening of new antineoplastic ally active Pt(II)and Pt(IV)-complexes the toxic action of trans-dihydroxy-cis-dichlorodiamine-platinum (IV) (oxoplatin) compared with that of cis-dichlorodiamineplatinum (II) (cis-DDP) on pancreatic islet B-cell function was investigated in the rat.